Publications

Somasundaram P, Farley MM, Rudy MA, Stefanoff DG, Shah M, Goli P, Heo J, Wang S, Tran NM, Watkins TA. 2023. Coordinated stimulation of axon regenerative and neurodegenerative transcriptional programs by Atf4 following optic nerve injury. eLife [Preprint].:2023.03.29.534798. doi: 10.1101/2023.03.29.534798 PMID: 37034690

Donthireddy L, Vonteddu P, Murthy T, Kwak T, Eraslan R, Podojil JR, Elhofy A, Boyne MT, Puisis JJ, Veglia F, Singh SS, Dotiwala F, Montaner LJ, Gabrilovich DI. 2022. ONP-302 Nanoparticles Inhibit Tumor Growth By Altering Tumor-Associated Macrophages And Cancer-Associated Fibroblasts. J Cancer 28;13(6):1933-1944 (2022) PMID: 35399717

Zaworski PG, Schwartz R, Burr J, Skutnik D, Mollin A, Kumar B, Ngumah Q, Welch E, Johnson B, Narasimhan J, Weetall M. 2022. Quantitation of Pax-6 protein in ocular impression cytology samples using an electrochemiluminescence immunoassay. Anal Biochem 1;656:114876. Epub 2022 Sep 2. PMID: 36058293

Karla K. Frietze, Alyssa M. Brown, Dividutta Das, Raymond G. Franks, Jessie Lee Cunningham, Michael Hayward, Joseph T. Nickels. 2022. Lipotoxicity reduces Rig-1 expression and activity leading to impaired autophagy and cell death. Autophagy, 2022, VOL. 18, NO. 1, 142–160 https://doi.org/10.1080/15548627.2021.1920818

Maillet E, Skutnik D, Jamison JA, Bailey D, Bacellar-Galdino M, & Garlick D. 2021. 2021. Anti-Inflammatory and Protective Effects of Topical Opthlamic (R)-DOI 0.01% in Allergic Conjunctivitis and Recurrent Intermediate Uveitis Disease Models in Rabbits. IOVS June 2021. 62, 232.

Gupta, A., Gullapalli, S., Pan, H. Ramos-Ortolaza, D. L., Hayward, M.D., Low, M.J. Pintar, J.E. Devi, L.A. I. 2021. Gomes Regulation of Opioid Receptors by Their Endogenous Opioid Peptides. Cell Mol Neurobiol 2021 July ; 41(5): 1103–1118. https://doi.org/10.1007%2Fs10571-020-01015-w

Christiano R. R. Alves PhD1, Ren Zhang MPH1, Alec J. Johnstone BS1, Reid Garner BS1, Eric J. Eichelberger BS1, Salomé Da Silva Duarte Lepez BA1, Vivian Yi BS1, Victoria Stevens B.S.1, Rebekah Poxson BA2, Rachel Schwartz BA2, Phillip Zaworski MS2, Kathryn J. Swoboda. 2020. MD1 Whole blood survival motor neuron protein levels correlate with severity of denervation in spinal muscular atrophy Muscle and Nerve DOI: 10.1002/mus.26995 2020 In Press

Gabitova-Cornell L, Surumbayeva A, Peri S, Franco-Barraza J, Restifo D, Weitz N, Ogier C, Goldman AR, Hartman TR, Francescone R, Tan Y, Nicolas E, Shah N, Handorf EA, Cai KQ, O'Reilly AM, Sloma I, Chiaverelli R, Moffitt RA, Khazak V, Fang CY, Golemis EA, Cukierman E, Astsaturov I. 2020. Cholesterol Pathway Inhibition Induces TGF-? Signaling to Promote Basal Differentiation in Pancreatic Cancer. Cancer Cell 38(4):567-583. e11. doi: 10.1016/j.ccell.2020.08.015. Epub 2020 Sep 24 PMID: 32976774

Makhov P, Sohn JA, Serebriiskii IG, Fazliyeva R, Khazak V, Boumber Y, Uzzo RG, Kolenko VM. 2020. CRISPR/Cas9 genome-wide loss-of-function screening identifies druggable cellular factors involved in sunitinib resistance in renal cell carcinoma. Br J Cancer Sep 24. doi: 10.1038/s41416-020-01087-x. Online ahead of print.

Muhua Yang, Christina Gallo-Ebert, Michael Hayward, Weidong Liu, Virginia McDonough and Joseph T. Nickels, Jr. 2020. Human insulin growth factor 2 mRNA binding protein 2 increases miR-33a/b inhibition of liver ABCA1 expression and alters low-density apolipoprotein levels in mice Mol and Cell Biol. 2020 Aug; 40(16): e00058-20. DIO: https://doi.org/10.1128%2FMCB.00058-20

Ramos DM, d'Ydewalle C, Gabbeta V, Dakka A, Klein SK, Norris DA, Matson J, Taylor SJ, Zaworski PG, Prior TW, Snyder PJ, Valdivia D, Hatem CL, Waters I, Gupte N, Swoboda KJ, Rigo F, Bennett CF, Naryshkin N, Paushkin S, Crawford TO, Sumner CJ. 2019. Age-dependent SMN expression in disease-relevant tissue and implications for SMA treatment. Clin Invest https://doi.org/10.1172/JCI124120. [Epub ahead of print] PMID: 31589162

Michael C. Van Zandt, G. Erik Jagdmann, Darren L. Whitehouse, Minkoo Ji, Jennifer Savoy, Olga Potapova, Alexandra Cousido-Siah, Andre Mitschler, Eduardo I. Howard, Anna Marie Pyle, and Alberto D. Podjarny. 2019. Discovery of N-Substituted 3-Amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic Acids as Highly Potent Third-Generation Inhibitors of Human Arginase I and II

Gallo-Ebert C, Francisco J, Liu HY, Draper R, Modi K, Hayward MD, Jones BK, Buiakova O, McDonough V, Nickels, JT Jr. 2018. Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease. J Biol Chem 296(16): 5956-5974 2018

Stroke, IL, Letourneau, JJ, Miller, TE, Xu, Y, Pechik, I, Savoly, DR, Ma, L, Sturzenbecker, LJ, Sabalski, J, Stein, PD, Webb, ML, Hilbert, DW. 2018. Treatment of Clostridium difficile infection with a small molecule inhibitor of toxin UDP-glucose hydrolysis activity. Antimicrob. Agents Chemother. (2018), 62, e00107-18

Letourneau, JJ, Stroke, IL, Hilbert, DW, Sturzenbecker, LJ, Marinelli, BA, Quintero, JG, Sabalski, J, Ma, L, Diller, DJ, Stein, PD, Webb, ML. 2018. Identification and initial optimization of inhibitors of Clostridium difficile (C. difficile) toxin B (TcdB). Bioorganic & Medicinal Chemistry Letters (2018), 28(4), 756-7

Strathmann EA, Peters M, Hosseinibarkooie S, Rigo FW, Bennett CF, Zaworski PG, Chen KS, Nothnagel M. 2018. Wirth B. Evaluation of potential effects of Plastin 3 overexpression and low-dose SMN-antisense oligonucleotides on putative biomarkers in spinal muscular atrophy mice. PLoS One. 2018 Sep 6;13(9):e0203398. doi: 10.1371/journal.pone.0203398. eCollection

Iyer CC, Corlett KM, Massoni-Laporte A, Duque SI, Madabusi N, Tisdale S, McGovern VL, Le TT, Zaworski PG, Arnold WD, Pellizzoni L, Burghes. 2018. Mild SMN missense alleles are only functional in the presence of SMN2 in mammals. AHM.Hum Mol Genet. 2018 Oct 1;27(19):3404-3416. doi: 10.1093/hmg/ddy251 PMID: 29982416

Decker DE, Skutnik D, Burr J, Pattison C, Cooley-Themm C, Linn DM, & Linn CL. 2018. 2018. GDF-15 Levels increase in Aqueous Humor Following Hypertonic Saline Injection into the Episcleral Vein in a Rat Claucoma Model. IOVS July 2018. 59, 3504.

Lisa D Berman-Booty , Rukiye Eraslan, Umesh Hanumegowda, Glenn H Cantor , Denise I Bounous , Evan B Janovitz, Beverly K Jones , Olesia Buiakova, Michael Hayward, Susan Wee. 2018. Systemic Loss of C-terminal Src Kinase (CSK) Expression Elicits Spontaneous Suppurative Inflammation in Conditional Knockout Mice. Vet Pathol 2018 Mar;55(2):331-340

Fedorova, Olga; Jagdmann, G. Erik; Adams, Rebecca L.; Yuan, Lin; Van Zandt, Michael; Pyle, Anna Marie . 2018. Small molecules that target group II introns are potent antifungal agents, Nature Chemical Biology (2018), 14 (12), 1073-1078 PMID: 30323219

Van Zandt, Michael C.; Savoy, Jennifer L.. 2018. Method of preparing (3r,4s)-3-acetamido-4-allyl-n-(tert-butyl) pyrrolidine-3-carboxamide, WO 2018209290 A1, 60 pp (2018)

Dworak, Jessica; Jagdmann, G. Erik; Van Zandt, Michael. 2018. Total synthesis of protectin DX, a potent proresolving lipid mediator, Abstracts of Papers, 256th ACS National Meeting & Exposition, Boston, MA, United States, August 19-23, 2018 (2018), ORGN-648

Rinis, Natalia; Golden, Jennifer E.; Marceau, Caleb D.; Carette, Jan E.; Van Zandt, Michael C.; Gilmore, Reid; Contessa, Joseph N. 2018. Editing N-Glycan Site Occupancy with Small-Molecule Oligosaccharyltransferase Inhibitors, Cell Chemical Biology (2018), 25(10), 1231-1241.e4 PMID: 30078634

Sjogren, Eric B.; Li, Jim; Chen, Lijing; Billedeau, Roland J.; Stanton, Timothy F.; Van Zandt, Michael; Whitehouse, Darren; Jagdmann, Gunnar E., Jr.; Petersen, Lene Raunkjaer; Parlati, Francesco; et al. 2018. Preparation of boron compounds and using compositions and methods for inhibiting arginase activity, WO 2018119440 A1, 220 pp (2018)

Sciavolino, Frank C.; Mathias, Gary; Van Zandt, Michael; Jagdmann, G. Erik; Dworak, Jessica. 2018. Compositions and methods relating to salts of specialized pro-resolving mediators of inflammation, WO 2017210604 A1, 109 pp (2018)

Gopinath, Smita; Kim, Myoungjoo V.; Rakib, Tasfia; Wong, Patrick W.; van Zandt, Michael; Barry, Natasha A.; Kaisho, Tsuneyasu; Goodman, Andrew L.; Iwasaki, Akiko. 2018. Topical application of aminoglycoside antibiotics enhances host resistance to viral infections in a microbiota-independent manner, Nature Microbiology (2018), 3(5), 611-621 PMID: 29632368

He S, Gleason J, Fik-Rymarkiewicz E, DiFiglia A, Bharathan M, Morschauser A, Djuretic I, Xu Y, Krakovsky M, Jankovic V, Buensuceso C, Edinger J, Herzberg U, Hofgartner W, Hariri R. 2017. Human Placenta-Derived Mesenchymal Stromal-Like Cells Enhance Angiogenesis via T Cell-Dependent Reprogramming of Macrophage Differentiation. Stem Cells 35(6): 1603-1613 PMID: 28233380

Kolb SJ, Coffey CS, Yankey JW, Krosschell K, Arnold WD, Rutkove SB, Swoboda KJ, Reyna SP, Sakonju A, Darras BT, Shell R, Kuntz N, Castro D, Parsons J, Connolly AM, Chiriboga CA, McDonald C, Burnette WB, Werner K, Thangarajh M, Shieh PB, Finanger E, Cudkowicz ME, McGovern MM, McNeil DE, Finkel R, Iannaccone ST, Kaye E, Kingsley A, Renusch SR, McGovern VL, Wang X, Zaworski PG, Prior TW, Burghes AHM, Bartlett A, Kissel JT. 2017. NeuroNEXT Clinical Trial Network on behalf of the NN101 SMA Biomarker Investigators. Natural history of infantile-onset spinal muscular atrophy. Ann Neurol. 2017 Dec;82(6):883-891. doi: 10.1002/ana.25101. Epub 2017 Dec 8. Free PMC article. Clinical Trial.

Sjogren, Eric B.; Li, Jim; Van Zandt, Michael; Whitehouse, Darren. . 2017. Compositions and methods for inhibiting arginase activity, WO 2017075363 A1, 54 pp (2017)

Zaworski P, von Herrmann KM, Taylor S, Sunshine SS, McCarthy K, Risher N, Newcomb T, Weetall M, Prior TW, Swoboda KJ, Chen KS, Paushkin S. 2016. SMN Protein Can Be Reliably Measured in Whole Blood with an Electrochemiluminescence (ECL) Immunoassay: Implications for Clinical Trials PLoS ONE 11(3): e0150640. PMID: 26953792

Kolb SJ, Coffey CS, Yankey JW, Krosschell K, Arnold WD, Rutkove SB, Swoboda KJ, Reyna SP, Sakonju A, Darras BT, Shell R, Kuntz N, Castro D, Iannaccone ST, Parsons J, Connolly AM, Chiriboga CA, McDonald C, Burnette WB, Werner K, Thangarajh M, Shieh PB, Finanger E, Cudkowicz ME, McGovern MM, McNeil DE, Finkel R, Kaye E, Kingsley A, Renusch SR, McGovern VL, Wang X, Zaworski PG, Prior TW, Burghes AHM, Bartlett A, Kissel JT, and the NeuroNEXT Clinical Trial Network and on behalf of the NN101 SMA Biomarker Investigators. 2016. Baseline results of the NeuroNEXT spinal muscular atrophy infant biomarker study. Ann Clin Transl Neurol 3(2): 132-145. PMID: 26900585

Gaponova AV, Nikonova AS, Deneka A, Kopp MC, Kudinov AE, Skobeleva N, Khazak V, Ogawa LS, Cai KQ, Duncan KE, Duncan JS, Egleston BL, Proia DA, Boumber Y, Golemis EA. 2016. A Novel HSP90 Inhibitor-Drug Conjugate to SN38 Is Highly Effective in Small Cell Lung Cancer. Clin Cancer Res. 2016 Oct 15;22(20):5120-5129. doi: 10.1158/1078-0432.CCR-15-3068.

Kolb, SJ, Coffey, CS, Yankey, JW et al. 2016. Baseline results of the NeuroNext spinal muscular atrophy infant biomarker study. Annals of Clinical and Translational Neurology, 21 January 2016;1-14

Arnold WD, Duque S, Iyer CC, Zaworski P, McGovern VL, Taylor SJ, von Herrmann KM, Kobayashi DT, Chen KS, Kolb SJ, Paushkin SV, Burghes AH. 2016. Normalization of Patient-Identified Plasma Biomarkers in SMNΔ7 Mice following Postnatal SMN Restoration. PLoS One. 2016 Dec 1;11(12):e0167077. doi: 10.1371/journal.pone.0167077. eCollection 2016. PMID: 27907033

Villasmil, M. L., J. Francisco, C. Gallo-Ebert, M. Donigan, H. Y. Liu, M. Brower, and J. T. Nickels, Jr. 2016. Ceramide signals for initiation of yeast mating-specific cell cycle arrest. Cell Cycle 15:441-454 PMID: 26726837

Czech C, Tang W, Bugawan T, Mano C, Horn C, Iglesias VA, Fröhner S, Zaworski PG, Paushkin S, Chen K, Kremer T. 2015. Biomarker for Spinal Muscular Atrophy: Expression of SMN in Peripheral Blood of SMA Patients and Healthy Controls. PLoS One 10(10): e0139950. PMID: 26468953

Iyer, CC, McGovern, VL, Murray, JD, Gombash, SE, Zaworski, PG, Foust, KD, Janssen, PM and Burghes, AH. 2015. Low levels of survival motor neuron protein are sufficient for normal muscle function in the SMNdelta7 mouse model of SMA. Hum Mol Genet 2015;24(21):6160-73 PMID: 26276812

McGovern, VL, Iyer, CC, Arnold, WD, Gombash, SE, Zaworski, PG, Blatnik, AJ, Foust, KD and Burghes, AH. 2015. SMN expression is required in motor neurons to rescue electrophysiological deficits in the SMNdelta7 mouse model of SMA. Hum Mol Genet 2015; 24(19):5524-41 PMID: 26206889

Pallai, R., A. Bhaskar, N. Barnett-Bernodat, C. Gallo-Ebert, J. T. Nickels, Jr., and L. M. Rice. 2015. Cancerous inhibitor of protein phosphatase 2A promotes premature chromosome segregation and aneuploidy in prostate cancer cells through association with shugoshin. Tumour Biol 36:6067-6074 PMID: 25736928

Pallai, R., A. Bhaskar, N. Barnett-Bernodat, C. Gallo-Ebert, M. Pusey, J. T. Nickels, Jr., and L. M. Rice. 2015. Leucine-rich repeat-containing protein 59 mediates nuclear import of cancerous inhibitor of PP2A in prostate cancer cells. Tumour Biol 36:6383-6390 PMID: 25833693

Joseph, B. K., H. Y. Liu, J. Francisco, D. Pandya, M. Donigan, C. Gallo-Ebert, C. Giordano, A. Bata, and J. T. Nickels, Jr. 2015. Inhibition of AMP Kinase by the Protein Phosphatase 2A Heterotrimer, PP2APpp2r2d. J Biol Chem 290:10588-10598 PMID: 25694423

Li J, Geisbush TR, Arnold WD, Rosen GD, Zaworski PG, Rutkove SB. 2014. A Comparison of Three Electrophysiological Methods for the Assessment of Disease Status in a Mild Spinal Muscular Atrophy Mouse Model. PLoS One 9(10): e111428.

Cherry JJ, Kobayashi DT, Lynes MM, Naryshkin NN, Tiziano FD, Zaworski PG, Rubin LL, Jarecki J. 2014. Assays for the Identification and Prioritization of Drug Candidates for Spinal Muscular Atrophy. Assay Drug Dev Technol 12(6): 315-341. PMID: 25147906

Gallo-Ebert C, Donigan M, Stroke IL, Swanson RN, Manners MT, Francisco J, Toner G, Gallagher D, Huang C-Y, Gygax SE, Webb M, Nickels JT Jr. 2014. Novel Antifungal Drug Discovery Based On Targeting Pathways Regulating The Fungal-Conserved Upc2 Transcription Factor. Antimicrob. Agents Chemother. (2014), 58(1), 258-266

Beeharry N, Banina E, Hittle J, Skobeleva N, Khazak V, Deacon S, Andrake M, Egleston BL, Peterson JR, Astsaturov I, Yen TJ. 2014. Re-purposing clinical kinase inhibitors to enhance chemosensitivity by overriding checkpoints. Cell Cycle;13(14):2172-91. doi: 10.4161/cc.29214

Stemmer, S and Shurshalina, A. 2014. Colonoscopic tattoo dye spillage mimics endometriosis on laparoscopy. J Minim Invasive Gynecol, 2014 Jul-Aug; 21(4):704-7 PMID: 24473152

Wandzioch, E., Pusey, M., Werda A., Bhaskar, A., & Rice, L.M. 2014. High expression of PME-1 in endometrial cancer cells promotes epithelial to mesenchymal transition via enhanced ERK, Akt, and β-catenin phosphorylation. Cancer Research. 2014 Aug 15; 74(16):4295-305 PMID: 24928782

Pusey, M., Bail, S., Werda, A., Rice, L.M. 2014. Protein Phosphatase Methylesterase 1: A potential therapeutic target and companion diagnostic marker for cancer. Cancer Cell & Microenvironment. 20141(5): e299

Rice, L.M., Donigan, M., Yang, M., Liu, W., Pandya, D., Joseph, B.K., Sodi, V., Gearhart, T.L., Yip, S.C., Bouchard, M., & Nickels, J.T. Jr. 2014. Protein phosphatase 2A regulates low-density lipoprotein uptake through regulating SREBP-2 DNA binding. Journal of Biological Chemistry, 2014 Jun 13; 289(24):17268-17279 PMID: 24770487

Gallo-Ebert, C., Donigan, M., Stroke, I.L., Swanson, R.N., Manners, M.T., Francisco, J., Toner, G., Gallagher, D., Huang, C.Y., Gygax, S.E., Webb, M. & Nickels, J.T., Jr. 2014. Novel antifungal drug discovery based on targeting pathways regulating the fungus-conserved Upc2 transcription factor. Antimicrob Agents Chemother 58, 258-266 PMID: 24145546

Hai, Yang; Edwards, Jennifer E.; Van Zandt, Michael C.; Hoffmann, Karl F.; Christianson, David W. 2014. Crystal structure of Schistosoma mansoni arginase, a potential drug target for the treatment of schistosomiasis, Biochemistry (2014), 53(28), 4671-4684 PMID: 25007099

Khazak V, Eyrisch S, Kato J, Tamanoi F, Golemis EA. 2013. A two-hybrid approach to identify inhibitors of the RAS-RAF interaction. Enzymes. 2013;33 Pt A:213-48. doi: 10.1016/B978-0-12-416749-0.00010-5.

Walsh, P., Overmyer, C., Hancock, C., Heffner, J., Walker, N., Nguyen, T., Shanholtzer, L., Caldera, E., Pusavat, J., Mordechai, E., Adelson, M.E. & Iacono, K.T. 2013. 2013. Is the interpretation of rapid antigen testing for respiratory syncytial virus as simple as positive or negative? Emerg Med J 31, 153-159 PMID: 23964062

Walsh, P., Overmyer, C., Hancock, C., Heffner, J., Walker, N., Nguyen, T., Shanholtzer, L., Pusavat, J., Mordechai, E., Adelson, M.E. & Iacono, K.T. 2013. Authors' response. Emerg Med J 31, 174 PMID: 24136121

McCourt, P., Gallo-Ebert, C., Gonghong, Y., Jiang, Y. & Nickels, J.T., Jr. 2013. PP2A(Cdc55) regulates G1 cyclin stability. Cell Cycle 12, 1201-1210. PMID: 23518505

Gallo-Ebert, C., Donigan, M., Liu, H.Y., Pascual, F., Manners, M., Pandya, D., Swanson, R., Gallagher, D., Chen, W., Carman, G.M. & Nickels, J.T., Jr. 2013. The yeast anaerobic response element AR1b regulates aerobic antifungal drug-dependent sterol gene expression. J Biol Chem 288, 35466-35477. PMID: 24163365

Yang, M., Liu, W., Pellicane, C., Sahyoun, C., Joseph, B.K., Gallo-Ebert, C., Donigan, M., Pandya, D., Giordano, C., Bata, A. & Nickels, J.T., Jr. 2013. Identification of miR-185 as a regulator of de novo cholesterol biosynthesis and low density lipoprotein uptake. J Lipid Res 55, 226-238. PMID: 24296663

Van Zandt, Michael; Jagdmann, Jr., Gunnar Erik. 2013. Ring constrained analogs as arginase inhibitors, WO 2013158262, 52 pp (2013)

Golebiowski, Adam; Whitehouse, Darren; Beckett, R. Paul; Van Zandt, Michael; Ji, Min Koo; Ryder, Todd R.; Jagdmann, Erik; Andreoli, Monica; Lee, Yung; Sheeler, Ryan; et al. 2013. Synthesis of quaternary α-amino acid-based arginase inhibitors via the Ugi reaction, Bioorganic & Medicinal Chemistry Letters (2013), 23(17), 4837-4841 PMID: 23886684

Zhang, Mingbao; Jagdmann, G. Erik, Jr.; Van Zandt, Michael; Beckett, Paul; Schroeter, Hagen. 2013. Enantioselective synthesis of orthogonally protected (2R,3R)-(-)-epicatechin derivatives, key intermediates in the de novo chemical synthesis of (-)-epicatechin glucuronides and sulfates, Tetrahedron Asymmetry (2013), 24(7), 362-373

Van Zandt, Michael C.; Whitehouse, Darren L.; Golebiowski, Adam; Ji, Min Koo; Zhang, Mingbao; Beckett, R. Paul; Jagdmann, G. Erik; Ryder, Todd R.; Sheeler, Ryan; Andreoli, Monica; et al. 2013. Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl) hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury, Journal of Medicinal Chemistry (2013), 56(6), 2568-2580 PMID: 23472952

Golebiowski, Adam; Paul Beckett, R.; Van Zandt, Michael; Ji, Min Koo; Whitehouse, Darren; Ryder, Todd R.; Jagdmann, Erik; Andreoli, Monica; Mazur, Adam; Padmanilayam, Manyian; et al. 2013. 2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors, Bioorganic & Medicinal Chemistry Letters (2013), 23(7), 2027-2030 PMID: 23453840

Zhang, Mingbao; Jagdmann, G. Erik; Van Zandt, Michael; Sheeler, Ryan; Beckett, Paul; Schroeter, Hagen. 2013. Chemical Synthesis and Characterization of Epicatechin Glucuronides and Sulfates: Bioanalytical Standards for Epicatechin Metabolite Identification, Journal of Natural Products (2013), 762), 157-169 PMID: 23356946

Kobayashi DT, Decker D, Zaworski P, Klott K, McGonigal J, Ghazal N, Sly L, Chung B, Vanderlugt J, Chen KS. 2012. Evaluation of peripheral blood mononuclear cell processing and analysis for Survival Motor Neuron protein. PLoS One. 2012;7(11):e50763 PMID: 23226377

Huang, L.P., Savoly, D., Sidi, A.A., Adelson, M.E., Mordechai, E. & Trama, J.P. 2012. CIP2A protein expression in high-grade, high-stage bladder cancer. Cancer Med 1, 76-81 PMID: 23342256

Hilbert, D.W., Paulish-Miller, T.E., Tan, C.K., Carey, A.J., Ulett, G.C., Mordechai, E., Adelson, M.E., Gygax, S.E. & Trama, J.P. 2012. Clinical Escherichia coli isolates utilize alpha-hemolysin to inhibit in vitro epithelial cytokine production. Microbes Infect 14, 628-638 PMID: 22326301

Stemmer, S.M., Adelson, M.E., Trama, J.P., Dorak, M.T. & Mordechai, E. 2012. Detection rates of trichomonas vaginalis, in different age groups, using real-time polymerase chain reaction. J Low Genit Tract Dis 16, 352-357 PMID: 22968052

Scher, M.B., Elbaum, M.B., Mogilevkin, Y., Hilbert, D.W., Mydlo, J.H., Sidi, A.A., Adelson, M.E., Mordechai, E. & Trama, J.P. 2012. Detecting DNA methylation of the BCL2, CDKN2A and NID2 genes in urine using a nested methylation specific polymerase chain reaction assay to predict bladder cancer. J Urol 188, 2101-2107 PMID: 23083854

Pallai, R., Bhaskar, A., Sodi, V. & Rice, L.M. 2012. Ets1 and Elk1 transcription factors regulate cancerous inhibitor of protein phosphatase 2A expression in cervical and endometrial carcinoma cells. Transcription 3, 323-335 PMID: 23117818

Gallo-Ebert, C., McCourt, P.C., Donigan, M., Villasmil, M.L., Chen, W., Pandya, D., Franco, J., Romano, D., Chadwick, S.G., Gygax, S.E. & Nickels, J.T., Jr. 2012. Arv1 lipid transporter function is conserved between pathogenic and nonpathogenic fungi. Fungal Genet Biol 49, 101-113. PMID: 22142782

Kruijf PD, Lim HD, Roumen L, Renjaan VA, Zhao J, Webb ML, Auld DS, Wijkmans JCHM, Zaman GJR, Smit MJ, Graaf CD, Leurs R. 2011. Identification of a Novel Allosteric Binding Site in the CXCR2. Chemokine Recept Mol Pharmacol 80:1108-1118 PMID: 21948388

Datta A, Adelson ME, Mogilevkin Y, Mordechai E, Sidi AA, Trama JP. 2011. Oncoprotein DEK as a tissue and urinary biomarker for bladder cancer. BMC Cancer. 2011 Jun 10; 11: 234 PMID: 21663673

Nolt JK*, Rice LM*, Gallo-Ebert C, Bisher ME, Nickels JT. 2011. PP2ACdc55 is required for multiple events during meiosis I. Cell Cycle. 2011 May 1; 10(9): 1420 – 34. (* These authors contributed equally.) PMID: 21455032

González-Pérez V, Reiner DJ, Alan JK, Mitchell C, Edwards LJ, Khazak V, Der CJ, Cox AD. 2010. Genetic and functional characterization of putative Ras/Raf interaction inhibitors in C. elegans and mammalian cells. J Mol Signal;5:2. doi: 10.1186/1750-2187-5-2.

Ho SB, Luu Y, Shekels LL, Batra SK, Kandarian B, Evans DB, Zaworski PG, Wolfe CL, Heinrikson RL. 2010. Activity of recombinant cysteine-rich domain proteins derived from the membrane-bound MUC17/Muc3 family mucins. Biochim Biophys Acta 1800(7):629-38. Epub 2010 Mar 20. PMID: 20332014

Huang LP, Adelson ME, Mordechai E, Trama JP. 2010. CIP2A expression is elevated in cervical cancer. Cancer Biomark. 2010 – 2011; 8(6): 309 – 17 PMID: 22072119

Biggs C, Walsh P, Overmyer CL, Gonzalez D, Feola M, Mordechai E, Adelson ME, and Iacono KT. 2010. Performance of influenza rapid antigen testing in influenza in emergency department patients. Emerg Med J. 27(1): 5-7 PMID: 20028996

Martin AG, Trama J, Crighton D, Ryan KM, Fearnhead HO. 2009. Activation of p73 and induction of Noxa by DNA damage requires NK-kappa B. Aging (Albany NY). 2009 Feb 18; 1(3):335-49 PMID: 20195489

Vermitsky, J-P., Chadwick, S.G., Self, M.J., Mordechai, E., Adelson, M.E., Nickels, J.T. Jr., and Gygax, S.E. 2009. CgUpc2 is the master regulator of ergosterol biosynthetic genes in Candida glabrata. Antimicrob. Agents Chemother. Manuscript in preparation.

Vermitsky, J.-P., Self, M.J., Chadwick, S.G., Katiyar, S.K., Mordechai, E., Adelson, M.E., Edlind, T.D., and Gygax, S.E. 2009. cAMP-PKA kinase Tpk3 negatively regulates Candida glabrata Pdr1. Antimicrob. Agents Chemother. Manuscript in preparation.

Prasad, A., Mordechai, E., Adelson, M.E., and Gygax, S.E. 2009. PBP4 Polymorphisms Generate Penicillin Tolerance in Group B Streptococcus. Nature Medicine. Manuscript in preparation.

Hilbert D, Paulish T, Mordechai E, Adelson ME, Gygax SE, and Trama JP. 2009. Antimicrobial non-susceptibility of cervico-vaginal and rectal Escherichia coli isolates is associated with phylogeny and plasmid carriage. Eur J Clin Microb Infect Dis. 28(11): 1399-403 PMID: 19639348

Hoey JG, Valois-Cruz F, Goldenberg H, Voskoboynik Y, Pfiffner J, Mordechai E, and Adelson ME. 2009. Development of an IgM capture-based ELISA for detection of acute infection with Bartonella henselae. Clin Vac Immun, 16(2): 282-284 PMID: 19052161

Morgan J, McCourt P, Rankin L, Swain E, Rice LM, and Nickels Jr. JT. 2009. Altering sphingolipid metabolism in yeast cells lacking the amphiphysin ortholog, Rvs161, re-initiates sugar transporter endocytosis. Eukaryot Cell, 8(5): 779-789 PMID: 19286982

McCourt P, Morgan J, Nickels Jr. JT. 2009. Stress-induced ceramide-activated protein phosphatase can compensate for loss of amphipysin-like activity in Saccharomyces cerevisiae and functions to reinitiate endocytosis. J Biol Chem, 284(18): 11930-11941 PMID: 19254955

Van Zandt, Michael C.; Doan, Brian; Sawicki, Diane R.; Sredy, Janet; Podjarny, Alberto D. 2009. Discovery of [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo [2,3-b]pyridin-1-yl]acetic acids as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications, Bioorganic & Medicinal Chemistry Letters (2009), 19(7), 2006-2008

Campbell PM, Lee KM, Ouellette MM, Kim HJ, Groehler AL, Khazak V, Der CJ. 2008. Ras-driven transformation of human nestin-positive pancreatic epithelial cells. Methods Enzymol;439:451-65. doi: 10.1016/S0076-6879(07)00431-4.

Rothweiler U, Czarna A, Krajewski M, Ciombor J, Kalinski C, Khazak V, Ross G, Skobeleva N, Weber L, Holak TA. 2008. Isoquinolin-1-one inhibitors of the MDM2-p53 interaction. ChemMedChem. 2008 Jul;3(7):1118-28. doi: 10.1002/cmdc.200800025.

Gygax SE, Vermitsky JP, Self MJ, Mordechai E, Adelson ME, Trama JP. 2008. Antifungal resistance in vaginal Candida clinical isolates. Antimicrob Agents Chemother, manuscript under review PMID: 18591262

Hilbert DW, Paulish TE, Mordechai E, Adelson ME, and Trama JP. 2008. O serogroups, phylogeny, and virulence factors of cervicovaginal and rectal Escherichia coli isolates. Eur J Clin Microb Infect Dis. 27(12): 1265-8 PMID: 18584221

Libby EK, Pascal KE, Mordechai E, Adelson ME, Trama JP. 2008. Atopobium vaginae triggers an innate immune response in an in vitro model of bacterial vaginosis. Microb Infect, 10(4):439-446 PMID: 18403235

Hilbert DW, Pascal KE, Libby EK, Mordechai E, Adelson ME, Trama JP. 2008. Uropathogenic Escherichia coli dominantly suppresses the innate immune response of bladder epithelial cells by a lipopolysaccharide- and Toll-like receptor 4-independent pathway. Microb Infect, 10(2):114-21 PMID: 18248759

Trama JP, Pascal KE, Zimmerman JA, Self MJ, Mordechai E, Adelson ME. 2008. Rapid detection of Atopobium vaginae and association with organisms implicated in bacterial vaginosis. Mol Cell Probes, 22(2):96-102 PMID: 17913456

McCool TL, Hoey JG, Montileone F, Goldenberg HB, Mordechai E, Adelson ME. 2008. Discovery and analysis of Bartonella henselae antigens for use in clinical serological assays. Diagn Microbiol Infect Dis, 60(1):17-23 PMID: 17889484

Khazak V, Astsaturov I, Serebriiskii IG, Golemis EA. 2007. Selective Raf inhibition in cancer therapy. Expert Opin Ther Targets;11(12):1587-609. Review. Erratum in: Expert Opin Ther Targets. 2009 Sep;13(9):1135.

Hao H, Muniz-Medina VM, Mehta H, Thomas NE, Khazak V, Der CJ, Shields JM. 2007. Context-dependent roles of mutant B-Raf signaling in melanoma and colorectal carcinoma cell growth. Mol Cancer Ther;6(8):2220-9.

Popowicz GM, Czarna A, Rothweiler U, Szwagierczak A, Krajewski M, Weber L, Holak TA. 2007. Molecular basis for the inhibition of p53 by Mdmx. Cell Cycle;6(19):2386-92.

Skobeleva N, Menon S, Weber L, Golemis EA, Khazak V. 2007. In vitro and in vivo synergy of MCP compounds with mitogen-activated protein kinase pathway- and microtubule-targeting inhibitors. Mol Cancer Ther;6(3):898-906.

Campbell PM, Groehler AL, Lee KM, Ouellette MM, Khazak V, Der CJ. 2007. K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol 3-kinase signaling. Cancer Res;67(5):2098-106.

Huang LP, Lyu SC, Clayberger C, Krensky AM. 2007. Granulysin-mediated tumor rejection in transgenic mice. J Immunol. 2007 Jan 1; 178(1):77-84 PMID: 17182542

Vermitsky JP, Self MJ, Chadwick SG, Trama JP, Mordechai E, Adelson ME. 2007. A survey of vaginal flora Candida species isolates from women of different age groups by use of species-specific PCR detection. J Clin Microbiol, 46(4):1501-1503 PMID: 18305136

Gygax SE, Schuyler JA, Trama JP, Mordechai E, Adelson ME. 2007. The detection of erythromycin and clindamycin resistance genes in both Group B Streptococcal clinical isolates and cervicovaginal/rectal swabs. Microb Drug Resist, 13(2):119-123 PMID: 17650964

Trama JP, Pascal KE, Zimmerman JA, Self MJ, Mordechai E, Adelson ME. 2007. Identification and genotyping of Molluscum Contagiosum virus from genital swab samples by Real-Time PCR and Pyrosequencing. J Clin Virol, 40(4):325-329 PMID: 17997134

Gygax SE, Schuyler JA, Kimmel LE, Trama JP, Mordechai E, Adelson, ME. 2006. Erythromycin and clindamycin resistance in Group B Streptococcal clinical isolates. Antimicrob Agents Chemother, 50(5):1875-7 PMID: 16641466

Loa CC, Mordechai E, Tilton RC, Adelson ME. 2006. Production of recombinant Bartonella henselae 17 kDa protein for antibody-capture enzyme-linked immunosorbent assay. Diagn Microbiol Infect Dis, 55(1):1-7 PMID: 16490335

Meer-Scherrer L, Adelson ME, Mordechai E, Tilton RC. 2006. Neuroborreliosis associated with Alzheimer’s disease. Curr Microbiol, 52(4):330-2 PMID: 16528463

Khazak V, Golemis EA, Weber L. 2005. Development of a yeast two-hybrid screen for selection of human Ras-Raf protein interaction inhibitors. Methods Mol Biol. 310:253-71.

Weber L. 2005. Chemistry for chemical genomics. Methods Mol Biol. 2005;310:11-24.

Trama JP, Adelson ME, Raphaelli I, Mordechai E. 2005. Detection of Candida species in vaginal samples in a clinical laboratory setting. Infect Dis Obstet Gynecol, 13(2):63-7 PMID: 16011995

Trama JP, Mordechai E, Adelson ME. 2005. Detection and identification of Candida species associated with candida vaginitis by Real- Time PCR and Pyrosequencing. Mol Cell Probes, 19(2):145-52 PMID: 15680216

Trama JP, Mordechai E, Adelson ME. 2005. Detection of Aspergillus fumigatus and a mutation that confers reduced susceptibility to itraconazole and posaconazole by Real-Time PCR and Pyrosequencing. J Clin Microbiol. 43(2):906-8 PMID: 15695702

Drisko J, Bischoff B, Giles C, Adelson ME, Rao RV, McCallum R. 2005. Evaluation of 5 probiotic products for bacteria by DNA extraction and PCR analysis. Dig Dis Sci, 50(6):1113-7 PMID: 15986864

Adelson ME, Feola M, Trama JP, Tilton RC, Mordechai E. 2005. Simultaneous detection of herpes simplex virus types 1 and 2 by Real-Time PCR and Pyrosequencing. J Clin Virol, 33(1):25-34 PMID: 15797362

Van Zandt, Michael C.; Jones, Michael L.; Gunn, David E.; Geraci, Leo S.; Jones, J. Howard; Sawicki, Diane R.; Sredy, Janet; Jacot, Jorge L.; DiCioccio, A. Thomas; Petrova, Tatiana; et al. 2005. Discovery of 3-[(4,5,7-Trifluorobenzothiazol-2-yl)methyl]indole- N-acetic Acid (Lidorestat) and Congeners as Highly Potent and Selective Inhibitors of Aldose Reductase for Treatment of Chronic Diabetic Complications, Journal of Medicinal Chemistry (2005), 48(9), 3141-3152 PMID: 15857120

Lu Y, Sakamuri S, Chen QZ, Keng YF, Khazak V, Illgen K, Schabbert S, Weber L, Menon SR. 2004. Solution phase parallel synthesis and evaluation of MAPK inhibitory activities of close structural analogues of a Ras pathway modulator. Bioorg Med Chem Lett. 2004 Aug 2;14(15):3957-62.

Adelson ME, Rao RV, Tilton RC, Cabets K, Eskow E, Fein L, Occi JL, Mordechai E. 2004. Prevalence of Borrelia burgdorferi, Bartonella species, Babesia microti, and Anaplasma phagocytophila in Ixodes scapularis collected in northern New Jersey. J Clin Microbiol, 42:2799-2801 PMID: 15184475

Meer-Scherrer L, Adelson ME, Mordechai E, Lottaz B, Tilton RC. 2004. Babesia microti infection in Europe. Curr Microbiol, 48(6):435-7 PMID: 15170239

Mogilyansky E, Loa CC, Adelson ME, Mordechai E, Tilton RC. 2004. Comparison of western immunoblots and the C6 Lyme antibody test for the laboratory detection of Lyme disease. Clin Diagn Lab Immunol, 11(5):924-929 PMID: 15358654

Loa CC, Adelson ME, Mordechai E, Raphaelli I, Tilton RC. 2004. Serological diagnosis of human babesiosis by IgG enzyme-linked immunoabsorbent assay. Curr Microbiol, 49:385-389 PMID: 15696612

Van Zandt, Michael C.; Sibley, Evelyn O.; McCann, Erin E.; Combs, Kerry J.; Flam, Brenda; Sawicki, Diane R.; Sabetta, Al; Carrington, Anne; Sredy, Janet; Howard, Eduardo; et al. 2004. Design and synthesis of highly potent and selective (2-arylcarbamoyl-phenoxy)-acetic acid inhibitors of aldose reductase for treatment of chronic diabetic complications, Bioorganic & Medicinal Chemistry Letters (2004), 12(21), 5661-5675 PMID: 15465344

Eskow E, Adelson ME, Rao RV, Mordechai E. 2003. Evidence for disseminated Mycoplasma fermentans in New Jersey residents with antecedent tick attachment and subsequent musculoskeletal symptoms. J Clin Rheumatol, 9:77-87 PMID: 17041434

Tilton RC. 2003. New tests for Lyme disease. Clin Microbiol Newsl, 25(19):145-149

Kato-Stankiewicz J, Hakimi I, Zhi G, Zhang J, Serebriiskii I, Guo L, Edamatsu H, Koide H, Menon S, Eckl R, Sakamuri S, Lu Y, Chen QZ, Agarwal S, Baumbach WR, Golemis EA, Tamanoi F, Khazak V. 2002. Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14398-403.

Eskow E, Rao RV, Mordechai E. 2001. Concurrent infection of the central nervous system by Borrelia burgdorferi and Bartonella henselae: Evidence for a novel tick-borne disease complex. Arch Neurol, 58:1357-1363 PMID: 11559306